Replenishing nucleii in established muscle cells doesn’t replace dying muscle cells. It might very well be that part of age related muscle loss is not due to lower count of muscle cells but due to other factors but sometimes muscle cells will die and that will produce muscle loss as people age when those aren’t replaced.
Cells die for many reasons. I don’t think you should expect zero muscle cells to die for any reason even if you help them replenish their nuclei.
My understanding is that muscle cells don’t just randomly die fast enough to account for age-related muscle loss. In young people post-development (i.e. people in their 20′s or early 30′s), it’s quite slow. Then with age, it accelerates. Fix whatever’s causing that accelerated loss, and muscle loss would be basically negligible.
What does “negligible” mean here? Negligible on what time scale? Because if the overarching question is “How do we stop or reverse aging to become amortal?” then any process of monotonic irreversible decline becomes important eventually.
Replenishing nucleii in established muscle cells doesn’t replace dying muscle cells. It might very well be that part of age related muscle loss is not due to lower count of muscle cells but due to other factors but sometimes muscle cells will die and that will produce muscle loss as people age when those aren’t replaced.
Cells die for many reasons. I don’t think you should expect zero muscle cells to die for any reason even if you help them replenish their nuclei.
My understanding is that muscle cells don’t just randomly die fast enough to account for age-related muscle loss. In young people post-development (i.e. people in their 20′s or early 30′s), it’s quite slow. Then with age, it accelerates. Fix whatever’s causing that accelerated loss, and muscle loss would be basically negligible.
What does “negligible” mean here? Negligible on what time scale? Because if the overarching question is “How do we stop or reverse aging to become amortal?” then any process of monotonic irreversible decline becomes important eventually.