Oh that’s entirely plausible. I should have emphasised that this may well be something that’s going on; it certainly doesn’t make it the only thing. Again, I have no expertise in this area—so mainly I’d like people with more knowledge than I to watch the video and draw their own conclusions.
My main takeaway with respect to the RCT in the post is that measurements of the 25-D being low in patients can’t be taken as evidence of deficiency if the 1,25-D levels are simultaneously high. So it’s premature to draw conclusions about non-deficient healthy people being ~92% safer than baseline.
It still seems right to me that not being deficient is important, and that vitamin D treatment is important.
Oh that’s entirely plausible. I should have emphasised that this may well be something that’s going on; it certainly doesn’t make it the only thing. Again, I have no expertise in this area—so mainly I’d like people with more knowledge than I to watch the video and draw their own conclusions.
My main takeaway with respect to the RCT in the post is that measurements of the 25-D being low in patients can’t be taken as evidence of deficiency if the 1,25-D levels are simultaneously high. So it’s premature to draw conclusions about non-deficient healthy people being ~92% safer than baseline.
It still seems right to me that not being deficient is important, and that vitamin D treatment is important.