In the case of orexin, my argument doesn’t just rest on the DEC2 gene.
The experiments that improved performance in sleep-deprived rhesus monkeys happened before the discovery of the link between the DEC2 mutation and orexin.
The observations in Astyanax mexicanus seem independent from my perspective. Attempts to make Astyanax mexicanus a model organism aren’t driven by sleep researchers but because it’s interesting for studying evolution.
Orexin deficiency causing Narcolepsy type 1 is independent of any findings about the DEC2 gene as well.
As far as the linked post of Scott goes, it says nothing about experiments on animals other than humans. Gene knockout studies in mice and Drosophila seem to me like a pretty good way to measure the influence of a gene.
I’m not sure if you have read the story of 5HTTLPR and all the independent studies which found it to have an effect, but if you haven’t you should.
In the case of orexin, my argument doesn’t just rest on the DEC2 gene.
The experiments that improved performance in sleep-deprived rhesus monkeys happened before the discovery of the link between the DEC2 mutation and orexin.
The observations in Astyanax mexicanus seem independent from my perspective. Attempts to make Astyanax mexicanus a model organism aren’t driven by sleep researchers but because it’s interesting for studying evolution.
Orexin deficiency causing Narcolepsy type 1 is independent of any findings about the DEC2 gene as well.
As far as the linked post of Scott goes, it says nothing about experiments on animals other than humans. Gene knockout studies in mice and Drosophila seem to me like a pretty good way to measure the influence of a gene.