Oh, I’m no expert! Just a skincare nerd who loves research-based information. I apologize if my wording was confusing.
I’m not quite sure why there’s so much concern in the comments. Yes, oral retinoids, such as Accutane, do carry significant health risks for humans, but that’s not the focus of this post. While high doses of oral retinoids have been associated with an increased risk of cancer in some animal studies, these studies typically involve doses much higher than those used in topical treatments.
When it comes to topical use, only trace amounts are absorbed, with adapalene having the lowest (<0.25 ng/mL). I tried really hard to find evidence of health concerns associated with topical retinoids, but they seem to be limited to skin irritation and a small potential risk of birth defects during pregnancy. In my opinion, adapalene is the best overall—it’s more accessible, less irritating, has additional anti-inflammatory benefits, and is more chemically stable than tretinoin while offering comparable results.
As for sunscreen, you’ve opened up a whole can of worms there, haha! I’d recommend checking out Dr Michelle Wong, aka Lab Muffin Beauty, who is a fantastic cosmetic chemist with great knowledge on myths like hormone disruption and on retinoids as well. You can find her at https://labmuffin.com/ or on YouTube. I can imagine you’re a busy man. If you have specific questions and my comment gives you a good feeling about my standards, feel free to ask – I’d be happy to look them up for you.
But to quickly summarize, there’s tons of misinformation out there about the dangers of sunscreens that’s not at all in line with the scientific consensus, made worse in the recent years by the “clean beauty” marketing / corporate opportunism movement. Sunscreens are rigorously tested and have huge safety margins (at least 100 times higher than the No Observed Adverse Effect Level or NOAEL), which take into account absorption through the skin and potential endocrine and other long-term effects.
Oh, I’m no expert! Just a skincare nerd who loves research-based information. I apologize if my wording was confusing.
I’m not quite sure why there’s so much concern in the comments. Yes, oral retinoids, such as Accutane, do carry significant health risks for humans, but that’s not the focus of this post. While high doses of oral retinoids have been associated with an increased risk of cancer in some animal studies, these studies typically involve doses much higher than those used in topical treatments.
When it comes to topical use, only trace amounts are absorbed, with adapalene having the lowest (<0.25 ng/mL). I tried really hard to find evidence of health concerns associated with topical retinoids, but they seem to be limited to skin irritation and a small potential risk of birth defects during pregnancy. In my opinion, adapalene is the best overall—it’s more accessible, less irritating, has additional anti-inflammatory benefits, and is more chemically stable than tretinoin while offering comparable results.
As for sunscreen, you’ve opened up a whole can of worms there, haha! I’d recommend checking out Dr Michelle Wong, aka Lab Muffin Beauty, who is a fantastic cosmetic chemist with great knowledge on myths like hormone disruption and on retinoids as well. You can find her at https://labmuffin.com/ or on YouTube. I can imagine you’re a busy man. If you have specific questions and my comment gives you a good feeling about my standards, feel free to ask – I’d be happy to look them up for you.
But to quickly summarize, there’s tons of misinformation out there about the dangers of sunscreens that’s not at all in line with the scientific consensus, made worse in the recent years by the “clean beauty”
marketing / corporate opportunismmovement. Sunscreens are rigorously tested and have huge safety margins (at least 100 times higher than the No Observed Adverse Effect Level or NOAEL), which take into account absorption through the skin and potential endocrine and other long-term effects.That’s extremely helpful, thank you!