And the mechanism involves increased cell turnover, which long-term tends to either increase stem cell depletion or increase cancer risk. There’s a tradeoff, which is why people don’t just do the thing normally. Maybe your natural tradeoff is wrong and you want to adjust it, but you have to recognize that it exists.
Can you link to a source about the increased cancer risk? Every source I’ve seen on this subject indicates retinoids DECREASE cancer risk, though I agree with you that this doesn’t make much intuitive sense.
Adapalene is used topically. Wikipedia doesn’t list skin fragility as a side effect but—as you can guess from its mechanism—it is one.
And the mechanism involves increased cell turnover, which long-term tends to either increase stem cell depletion or increase cancer risk. There’s a tradeoff, which is why people don’t just do the thing normally. Maybe your natural tradeoff is wrong and you want to adjust it, but you have to recognize that it exists.
Can you link to a source about the increased cancer risk? Every source I’ve seen on this subject indicates retinoids DECREASE cancer risk, though I agree with you that this doesn’t make much intuitive sense.