My impression is that caloric restriction has a threshold effect—there’s a mechanism that gets invoked when the calories are low enough, though it isn’t a sharp boundary. Is this at all accurate?
This matches what I’ve read—that the body switches into different metabolic modes based on caloric abundance. Entire patterns of gene expression change.
Today we spend almost all of our time in the caloric-abundance high burn mode, and this accelerates metabolic aging.
However, I’m also thinking that caloric burn accelerates some aging processes by itself, but it is quite difficult to dissociate that from everything else—insulin, gene expression, etc etc
My impression is that caloric restriction has a threshold effect—there’s a mechanism that gets invoked when the calories are low enough, though it isn’t a sharp boundary. Is this at all accurate?
This matches what I’ve read—that the body switches into different metabolic modes based on caloric abundance. Entire patterns of gene expression change.
Today we spend almost all of our time in the caloric-abundance high burn mode, and this accelerates metabolic aging.
However, I’m also thinking that caloric burn accelerates some aging processes by itself, but it is quite difficult to dissociate that from everything else—insulin, gene expression, etc etc