Scott Alexander for psychiatry and drugs and many other topics
Paul Graham for startups specifically, but his essays cover a much wider space
Scott Adams for persuasion, humor, and recently a lot of political commentary—not neutral; he has his own agendas
Robin Hanson—Economics, esp. long-term, very much out-of-distribution thinking
Zvi Mowshowitz for AI news (and some other research-heavy topics; previously COVID-19)
I second Patrick McKenzie.
Scott Alexander for psychiatry and drugs and many other topics
Paul Graham for startups specifically, but his essays cover a much wider space
Scott Adams for persuasion, humor, and recently a lot of political commentary—not neutral; he has his own agendas
Robin Hanson—Economics, esp. long-term, very much out-of-distribution thinking
Zvi Mowshowitz for AI news (and some other research-heavy topics; previously COVID-19)
I second Patrick McKenzie.