This is also a huge epidemiological study that showed lower cholesterol INCREASED risk for death from cardiovascular disease in women. In men, cholesterol and death followed a U-shaped curve, so men with the highest and lowest cholesterol were at increased risk for death. Of course, with the caveat that this is also not a randomized trial and thus not quality evidence, it does call into question whether the increase in cholesterol seen in the 1st study was a good thing or a bad thing.
We have higher quality data from randomized trials that show Statins, which lower cholesterol, don’t reduce mortality when used for primary prevention.
This is also a huge epidemiological study that showed lower cholesterol INCREASED risk for death from cardiovascular disease in women. In men, cholesterol and death followed a U-shaped curve, so men with the highest and lowest cholesterol were at increased risk for death. Of course, with the caveat that this is also not a randomized trial and thus not quality evidence, it does call into question whether the increase in cholesterol seen in the 1st study was a good thing or a bad thing.
We have higher quality data from randomized trials that show Statins, which lower cholesterol, don’t reduce mortality when used for primary prevention.