I think Steve Hsu has written some about the evidence for additivity on his blog (Information Processing). He also talks about it a bit in section 3.1 of this paper.
So I only briefly read through the section of the paper, but not really sure whether it applies to my hypothesis: My hypothesis isn’t about there being gene-combinations that are useful which were selected for, but just about there being gene-combinations that coincidentally work better without there being strong selection pressure for those to quickly rise to fixation. (Also yeah for simpler properties like how much milk is produced I’d expect a much larger share of the variance to come from genes which have individual contributions. Also for selection-based eugenics the main relevant thing are the genes which have individual contribution. (Though if we have precise ability to do gene editing we might be able to do better and see how to tune the hyperparameters to fit well together.))
Please let me know whether I’m missing something though.
I think Steve Hsu has written some about the evidence for additivity on his blog (Information Processing). He also talks about it a bit in section 3.1 of this paper.
Thanks.
So I only briefly read through the section of the paper, but not really sure whether it applies to my hypothesis: My hypothesis isn’t about there being gene-combinations that are useful which were selected for, but just about there being gene-combinations that coincidentally work better without there being strong selection pressure for those to quickly rise to fixation.
(Also yeah for simpler properties like how much milk is produced I’d expect a much larger share of the variance to come from genes which have individual contributions. Also for selection-based eugenics the main relevant thing are the genes which have individual contribution. (Though if we have precise ability to do gene editing we might be able to do better and see how to tune the hyperparameters to fit well together.))
Please let me know whether I’m missing something though.