I didn’t read this carefully—but it’s largely irrelevant. Adult editing probably can’t have very large effects because developmental windows have passed; but either way the core difficulty is in editor delivery. Germline engineering does not require better gene targets—the ones we already have are enough to go as far as we want. The core difficulty there is taking a stem cell and making it epigenomically competent to make a baby (i.e. make it like a natural gamete or zygote).
I didn’t read this carefully—but it’s largely irrelevant. Adult editing probably can’t have very large effects because developmental windows have passed; but either way the core difficulty is in editor delivery. Germline engineering does not require better gene targets—the ones we already have are enough to go as far as we want. The core difficulty there is taking a stem cell and making it epigenomically competent to make a baby (i.e. make it like a natural gamete or zygote).