This is orthogonal to your point, but you’re conflating two different descriptions of the mechanisms of aging when you attribute “7 hallmarks of aging” to Aubrey de Grey. Aubrey talks about seven distinct forms of damage that result from metabolic activity. There’s a separate discussion that addresses 9 hallmarks, though that is less attributable to any single researcher. The framework has been adopted by the NIH, AFAR, and extensively discussed in Sinclair’s book Lifespan.
There’s a fair amount of overlap between the two, but they’re distinct frameworks. de Grey’s theory talks about 7 distinct types of cellular damage that might be mitigated by separate interventions. (e.g. “mitochondrial mutations” by outsourcing the production of proteins, “extracellular linkages” by AGE breakers). The 9 Hallmarks approach identifies vaguer clouds of disfunction, only some of which are amenable to direct intervention. (e.g. “epigenetic alterations”, “loss of proteostasis”, “deregulated nutrient sensing”).
This is orthogonal to your point, but you’re conflating two different descriptions of the mechanisms of aging when you attribute “7 hallmarks of aging” to Aubrey de Grey. Aubrey talks about seven distinct forms of damage that result from metabolic activity. There’s a separate discussion that addresses 9 hallmarks, though that is less attributable to any single researcher. The framework has been adopted by the NIH, AFAR, and extensively discussed in Sinclair’s book Lifespan.
There’s a fair amount of overlap between the two, but they’re distinct frameworks. de Grey’s theory talks about 7 distinct types of cellular damage that might be mitigated by separate interventions. (e.g. “mitochondrial mutations” by outsourcing the production of proteins, “extracellular linkages” by AGE breakers). The 9 Hallmarks approach identifies vaguer clouds of disfunction, only some of which are amenable to direct intervention. (e.g. “epigenetic alterations”, “loss of proteostasis”, “deregulated nutrient sensing”).
I fixed it in the text. From https://www.lesswrong.com/posts/RcifQCKkRc9XTjxC2/anti-aging-state-of-the-art I got the impression that they frameworks are very similar so I took the to be more or less the same thing.