I’m the PI (supervisor) on the replication of the creatine trial. We have finished the trial but not the data entry+analysis. Extremely tentatively, it looks like the effect replicates but with much smaller effect size. If this result remains after data entry+analysis are complete, then I’d say this is a positive update for cognitive benefits of creatine—given that the prior for this to work was pretty low (publication bias, and so on), I’d say that one trial with a large effect size and one with a small effect size is more convincing than just one with a large effect size.
But really, the result might still change in the process of us double-checking things. It’s just my best guess right now. The preprint will hopefully appear in the course of the year.
Hi,
I’m the PI (supervisor) on the replication of the creatine trial. We have finished the trial but not the data entry+analysis. Extremely tentatively, it looks like the effect replicates but with much smaller effect size. If this result remains after data entry+analysis are complete, then I’d say this is a positive update for cognitive benefits of creatine—given that the prior for this to work was pretty low (publication bias, and so on), I’d say that one trial with a large effect size and one with a small effect size is more convincing than just one with a large effect size.
But really, the result might still change in the process of us double-checking things. It’s just my best guess right now. The preprint will hopefully appear in the course of the year.
This doesn’t seem to be published yet (or I can’t find it), but any updates on publication dates or your independent impression?
Thank you a lot! I’m looking forward to the preprint. If you don’t mind me asking, was your sample fully vegetarian?
We had two groups, one vegetarian/vegan, and one omnivore.