449 people. Specifically, they observed no difference in survival between heparin users/non-users overall, but in the very-high-D-dimer subset (or in people with lots of sepsis‐induced coagulopathy), survival seemed to be better with heparin.
This link carries no new information yet, but seems to be a placeholder for a future review paper on this topic.
The “blood coagulation as a major contributor to death” bit generally matches pretty well with some early results where high D-dimer predicted worse rates of mortality fairly reliably, since D-dimer is basically a problematic-blood-clot indicator.
There’s a potential complicating factor for the elderly, which is that many of them are already on anticoagulants (to mitigate stroke-risk). And going on some experiences of my grandparents, it seems to be hard to navigate the risks mitigated with anticoagulants with the risk of bleeding out unless you’re pretty careful. All the same, it looks like a promising line of improvement to treatment of severe COVID-19.
Here’s a paper that situationally agrees with you on anticoagulants… Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy
449 people. Specifically, they observed no difference in survival between heparin users/non-users overall, but in the very-high-D-dimer subset (or in people with lots of sepsis‐induced coagulopathy), survival seemed to be better with heparin.
This link carries no new information yet, but seems to be a placeholder for a future review paper on this topic.
The “blood coagulation as a major contributor to death” bit generally matches pretty well with some early results where high D-dimer predicted worse rates of mortality fairly reliably, since D-dimer is basically a problematic-blood-clot indicator.
There’s a potential complicating factor for the elderly, which is that many of them are already on anticoagulants (to mitigate stroke-risk). And going on some experiences of my grandparents, it seems to be hard to navigate the risks mitigated with anticoagulants with the risk of bleeding out unless you’re pretty careful. All the same, it looks like a promising line of improvement to treatment of severe COVID-19.
Nitpick: __ice9 has 2 underscores, not 1.