Basic question about the two-dose one-dose cost-benefit analysis:
What is the prior to have on how soon you need the second dose to confer long-term immunity? The data we have is on 3 weeks between dose 1 and 2, and that shows 92% immunity reached with the single dose, but now it sounds like e.g. the UK is gonna hold back that second dose for some amount of time, and I can imagine that being like 2 months or so. Anyone know how long is too long?
Here is how it works for the MMR vaccine (measles, mumps, and rubella):
Children should get two doses of MMR vaccine, starting with the first dose at 12 to 15 months of age, and the second dose at 4 through 6 years of age.
Or here are the WHO recommendations for various vaccines (from the larger source here) for children. The times in the Booster Dose column span months or years. This doesn’t quite answer the question of how soon you need to be, but does provide an intuition for the orders of magnitude which are typically involved, at least for children. Though besides age, I suppose part of the epidemiological reasoning here must involve not just the reaction of the immune system, but also the prevalence of the disease.
Basic question about the two-dose one-dose cost-benefit analysis:
What is the prior to have on how soon you need the second dose to confer long-term immunity? The data we have is on 3 weeks between dose 1 and 2, and that shows 92% immunity reached with the single dose, but now it sounds like e.g. the UK is gonna hold back that second dose for some amount of time, and I can imagine that being like 2 months or so. Anyone know how long is too long?
Reasoning by analogy, via some googling:
Here is how it works for the MMR vaccine (measles, mumps, and rubella):
Or here are the WHO recommendations for various vaccines (from the larger source here) for children. The times in the Booster Dose column span months or years. This doesn’t quite answer the question of how soon you need to be, but does provide an intuition for the orders of magnitude which are typically involved, at least for children. Though besides age, I suppose part of the epidemiological reasoning here must involve not just the reaction of the immune system, but also the prevalence of the disease.