It seems fairly straightforward to test whether a chromosome transfer protocol results in physical/genetic damage in small scale experiments (e.g. replace chromosome X in cell A with chromosome Y in cell B, culture cell A, examine cell A’s chromosomes under a microscope + sequence the genome).
The epigenetics seems harder. Having a good gears-level understanding of the epigenetics of development seems necessary, because then you’d know what to measure in an experiment to test whether your protocol was epigenetically sound.
It seems fairly straightforward to test whether a chromosome transfer protocol results in physical/genetic damage in small scale experiments (e.g. replace chromosome X in cell A with chromosome Y in cell B, culture cell A, examine cell A’s chromosomes under a microscope + sequence the genome).
The epigenetics seems harder. Having a good gears-level understanding of the epigenetics of development seems necessary, because then you’d know what to measure in an experiment to test whether your protocol was epigenetically sound.