Consider mixing your fourth dose. If you got three doses of Pfizer then get Moderna for your fourth dose. Or vice versa.
While Moderna and Pfizer are both mRNA vaccines, they are not identical and have subtle but meaningful differences. (See my previous post: Moderna vs. Pfizer: Is there a difference?)
This was confirmed yesterday from another peer-reviewed study. Scientists found that while the two different shots have the same impact on neutralizing antibodies, they have a different impact on Fc-functional antibodies, which target the whole surface of the spike protein. They also had a different impact on T-cell mechanisms. If you mix vaccines you have the potential to maximize protection.
If you’re not sure which to go for, or already mixed, I recommend defaulting to Moderna for additional doses. It seems to have slightly better durability.
Both the parents are now 4th shot Moderna-fied. Interestingly, my mother had never had side effects from Pfizer doses but Moderna did produce one night of mild body aches.
Recommendation to mix: https://yourlocalepidemiologist.substack.com/p/fourth-dose-q-and-a?s=r
If you’re not sure which to go for, or already mixed, I recommend defaulting to Moderna for additional doses. It seems to have slightly better durability.
Both the parents are now 4th shot Moderna-fied. Interestingly, my mother had never had side effects from Pfizer doses but Moderna did produce one night of mild body aches.