“New role in cells suggested for ATP
Known as an energy carrier, molecule can also solubilize proteins”
“investigated the effects of ATP on the aggregation of several proteins. They found that ATP could prevent the aggregation of two proteins known to form amyloid clumps. For a third protein, ATP was further able to dissolve fibers of already aggregated protein. And ATP kept proteins in boiled egg white from aggregating.
“Most healthy cell functions require that proteins remain soluble at enormous intracellular concentrations, without aggregating into pathogenic deposits,” write Allyson M. Rice and Michael K. Rosen of the University of Texas Southwestern Medical Center in a perspective accompanying the paper. “The cell may exploit a natural hydrotrope to keep itself in a functioning, dynamic state.”
“New role in cells suggested for ATP Known as an energy carrier, molecule can also solubilize proteins”
“investigated the effects of ATP on the aggregation of several proteins. They found that ATP could prevent the aggregation of two proteins known to form amyloid clumps. For a third protein, ATP was further able to dissolve fibers of already aggregated protein. And ATP kept proteins in boiled egg white from aggregating.
“Most healthy cell functions require that proteins remain soluble at enormous intracellular concentrations, without aggregating into pathogenic deposits,” write Allyson M. Rice and Michael K. Rosen of the University of Texas Southwestern Medical Center in a perspective accompanying the paper. “The cell may exploit a natural hydrotrope to keep itself in a functioning, dynamic state.”
http://cen.acs.org/articles/95/i21/New-role-cells-suggested-ATP.html