Suppose some variant like the SA one is vaccine-evading and some people will have to vaccinate a second time with an adapted vaccine. What are our priors for the safety of vaccinating repeatedly this way (either with the same or different delivery methods)? If we have two vaccines that are pretty safe, are side effects of vaccinating with the first one and then vaccinating with the second, similar one almost surely on the order of side effects from using just one kind of vaccine?
I would expect the prior to be to end up with something similar to the flu vaccine, which we try to get everyone to take approximately yearly and have more safety concerns about people not taking it.
Suppose some variant like the SA one is vaccine-evading and some people will have to vaccinate a second time with an adapted vaccine. What are our priors for the safety of vaccinating repeatedly this way (either with the same or different delivery methods)? If we have two vaccines that are pretty safe, are side effects of vaccinating with the first one and then vaccinating with the second, similar one almost surely on the order of side effects from using just one kind of vaccine?
I would expect the prior to be to end up with something similar to the flu vaccine, which we try to get everyone to take approximately yearly and have more safety concerns about people not taking it.