In our time, we morally justify the forcible hospitalization and medication of suicidal people until they aren’t suicidal anymore. With Friendly AI, this moral justification may remain true in the future, and once you’re on drugs or other brain enhancements, you’ll probably love life and think your self from your first life absolutely insane for preferring death to glorious existence. Again, I think your desire for deep connections with other people is likely to be nearly immediately fixable in the future. This does sound a little dystopian, but I don’t think there exist very many wake-up futures in which your existential misery can not be fixed.
Resistance is illogical, you will be upgraded.