The other hypotheses were located in similar manner, though. And far too much has to be ignored to generalize from said animal organs or said microscopic animals. Generalization from kidneys to brains is particularly dubious. Especially as great many of said frozen corpses are frozen corpses precisely because of their brain’s unusual fragility with regards to loss of blood supply.
edit: The issue is not with cryonics in principle. The issue is with cryonics as it is. Similar to the people jumping off towers with some wings vs an airplane. Seeing a bird fly really doesn’t make for a case that you can fly by your own muscular power with some homemade birdlike wings, with the early prototype, in fact it makes for the opposite case (as none of the birds are as heavy as you are). Evidence against a hypothesis can locate it too.
edit2: And with regards to information theory, it is absolutely trivial and clear cut: given that there is a mapping from a larger phase space, to a smaller phase space, meaning that some information is irretrievably lost. It is not there anymore for any super-intelligence to deduce. Just that. This summarizes everything information theory has to say about the issue. Whenever that information is important or not, that is a question of neurobiology.
With regards to the future cryonics, there’s two possibilities:
1: Revival. If we can cryopreserve brain tissue, revive it, and it retains learning, that would be an indication that the procedure works.
2: Fixatives. The opposite of revival. If we find out how exactly the memories are stored, we can develop a fixative mix that would lock those proteins in place by cross linking, i.e. adding strong chemical bonds in place of weak intermolecular bonds. That is a drastic measure which would require pumping the brain full of highly toxic, carcinogenic chemicals such as formaldehyde. (This may even permit room-temperature storage, or may require cooling). Without knowledge of how it is stored one can make a shot in the dark and hope that particular fixatives would work.
Current cryonics is neither, and is hence not taken seriously by experts in any fields expertise in which is actually necessary for evaluating whenever the lost information is relevant. I’ve a nagging suspicion that an effective procedure for future uploading would end with a brain diced into small slices and stored at room temperature in a jar of some cheap cocktail of fixatives. With all molecules neatly cross linked in their original places rather than unravelled and detached by solvents.
Well, I’m mostly interested in brain/mind-preservation in general—I don’t care if it’s by fixatives or freezing. I’ve heard discussion of “plastination” which seems similar to your point #2. Even aside from whether it’s more likely to actually work or not, it seems like it could be cheaper and more practical as well. I’m all in favour of more research along those lines.
(Earlier you gave me the impression that you thought the entire concept of preserving a brain was some wild fantasy not even worth thinking about (ie the typical opinion of Very Serious People), but this seems more like you were disagreeing with the effectiveness of cyroprotectants specifically, which I don’t have strong grounds for an opinion on).
Keep in mind that cryonics generally advertises the possibility of in-place repair of some kind, biological revival. The uploading possibilities are not optimized for. The kind of compounds you would want to add to preserve information (to avoid loss due to denaturation) are very toxic at much lower concentrations.
With regards to plastination, it has the extra destructive steps of trying to get a solid in the end, and to avoid cutting it into pieces.
ie the typical opinion of Very Serious People
I doubt it’s the typical opinion, really. If by very serious people you mean top scientists and the like… they have more complex opinions because due to the training and intelligence they can relatively effortlessly hold complicated relations in the heads. Opinions could be “no future technology will permit revival of [currently] frozen corpses”, “freezing and biological revival is unlikely to ever be workable”, and so on.
And on a tangent, correct opinions about such topics are a matter of knowledge and capability involved in simulating said processes in your head.
To deal with a simpler example without cryoprotectants (e.g. as described here). When a scientist with relevant expertise considers dropping a head into liquid nitrogen, within mere seconds they do a lot of work in their heads—they correctly estimate the cooling rate inside the head (going to take many minutes to freeze), they picture the ice crystals growing, everything other than pure water (up until −18 celsius) getting squished into inter-crystal spaces and getting ripped and scraped in the process (irreversibly losing a lot of information due to many to one transitions—and no redundancy will help you when the ‘redundant’ storage is subject to same destruction), chemical damage due to high salinity (also irreversibly losing information), and so on and so forth.
The rationalists on the other hand seem not to even realize that such considerations are required, let alone occur. It does not matter for how long you are going to think about it if your thought is not even simulating any destructive processes that occur.
With cryoprotectants, the issue is considerably more complicated, with lesser possibility for a simple conclusive disproof, but no better reason to expect it to work (pumping brain full of solvents at denaturing concentrations doesn’t seem like a good idea, and all those references to rabbit kidneys at much lower concentrations mostly serve as evidence of bad faith rather than evidence that it works). The one perhaps big advantage though is that at least the connectivity map would be readable for sure, that’s provided that the cryo-protectants actually do reach most of the brain, which is uncertain as well.
It’s clear at this point that your opinion is not as extreme as I the impression I originally got (unlike some people) and I don’t really disagree much with what you say here. I too am skeptical of current methods (and I’m not signed up for this and other reasons), but I’d like to see further work on both traditional cyropreservation and other methods such as plastination, taking into account any new research on memory formation and storage. The idea being to get to a point where we can preserve an animal brain and check to see that the important information seems to be preserved (even if we can’t read it back out yet).
The other hypotheses were located in similar manner, though. And far too much has to be ignored to generalize from said animal organs or said microscopic animals. Generalization from kidneys to brains is particularly dubious. Especially as great many of said frozen corpses are frozen corpses precisely because of their brain’s unusual fragility with regards to loss of blood supply.
edit: The issue is not with cryonics in principle. The issue is with cryonics as it is. Similar to the people jumping off towers with some wings vs an airplane. Seeing a bird fly really doesn’t make for a case that you can fly by your own muscular power with some homemade birdlike wings, with the early prototype, in fact it makes for the opposite case (as none of the birds are as heavy as you are). Evidence against a hypothesis can locate it too.
edit2: And with regards to information theory, it is absolutely trivial and clear cut: given that there is a mapping from a larger phase space, to a smaller phase space, meaning that some information is irretrievably lost. It is not there anymore for any super-intelligence to deduce. Just that. This summarizes everything information theory has to say about the issue. Whenever that information is important or not, that is a question of neurobiology.
With regards to the future cryonics, there’s two possibilities:
1: Revival. If we can cryopreserve brain tissue, revive it, and it retains learning, that would be an indication that the procedure works.
2: Fixatives. The opposite of revival. If we find out how exactly the memories are stored, we can develop a fixative mix that would lock those proteins in place by cross linking, i.e. adding strong chemical bonds in place of weak intermolecular bonds. That is a drastic measure which would require pumping the brain full of highly toxic, carcinogenic chemicals such as formaldehyde. (This may even permit room-temperature storage, or may require cooling). Without knowledge of how it is stored one can make a shot in the dark and hope that particular fixatives would work.
Current cryonics is neither, and is hence not taken seriously by experts in any fields expertise in which is actually necessary for evaluating whenever the lost information is relevant. I’ve a nagging suspicion that an effective procedure for future uploading would end with a brain diced into small slices and stored at room temperature in a jar of some cheap cocktail of fixatives. With all molecules neatly cross linked in their original places rather than unravelled and detached by solvents.
Well, I’m mostly interested in brain/mind-preservation in general—I don’t care if it’s by fixatives or freezing. I’ve heard discussion of “plastination” which seems similar to your point #2. Even aside from whether it’s more likely to actually work or not, it seems like it could be cheaper and more practical as well. I’m all in favour of more research along those lines.
(Earlier you gave me the impression that you thought the entire concept of preserving a brain was some wild fantasy not even worth thinking about (ie the typical opinion of Very Serious People), but this seems more like you were disagreeing with the effectiveness of cyroprotectants specifically, which I don’t have strong grounds for an opinion on).
Keep in mind that cryonics generally advertises the possibility of in-place repair of some kind, biological revival. The uploading possibilities are not optimized for. The kind of compounds you would want to add to preserve information (to avoid loss due to denaturation) are very toxic at much lower concentrations.
With regards to plastination, it has the extra destructive steps of trying to get a solid in the end, and to avoid cutting it into pieces.
I doubt it’s the typical opinion, really. If by very serious people you mean top scientists and the like… they have more complex opinions because due to the training and intelligence they can relatively effortlessly hold complicated relations in the heads. Opinions could be “no future technology will permit revival of [currently] frozen corpses”, “freezing and biological revival is unlikely to ever be workable”, and so on.
And on a tangent, correct opinions about such topics are a matter of knowledge and capability involved in simulating said processes in your head.
To deal with a simpler example without cryoprotectants (e.g. as described here). When a scientist with relevant expertise considers dropping a head into liquid nitrogen, within mere seconds they do a lot of work in their heads—they correctly estimate the cooling rate inside the head (going to take many minutes to freeze), they picture the ice crystals growing, everything other than pure water (up until −18 celsius) getting squished into inter-crystal spaces and getting ripped and scraped in the process (irreversibly losing a lot of information due to many to one transitions—and no redundancy will help you when the ‘redundant’ storage is subject to same destruction), chemical damage due to high salinity (also irreversibly losing information), and so on and so forth.
The rationalists on the other hand seem not to even realize that such considerations are required, let alone occur. It does not matter for how long you are going to think about it if your thought is not even simulating any destructive processes that occur.
With cryoprotectants, the issue is considerably more complicated, with lesser possibility for a simple conclusive disproof, but no better reason to expect it to work (pumping brain full of solvents at denaturing concentrations doesn’t seem like a good idea, and all those references to rabbit kidneys at much lower concentrations mostly serve as evidence of bad faith rather than evidence that it works). The one perhaps big advantage though is that at least the connectivity map would be readable for sure, that’s provided that the cryo-protectants actually do reach most of the brain, which is uncertain as well.
It’s clear at this point that your opinion is not as extreme as I the impression I originally got (unlike some people) and I don’t really disagree much with what you say here. I too am skeptical of current methods (and I’m not signed up for this and other reasons), but I’d like to see further work on both traditional cyropreservation and other methods such as plastination, taking into account any new research on memory formation and storage. The idea being to get to a point where we can preserve an animal brain and check to see that the important information seems to be preserved (even if we can’t read it back out yet).