I am an absolute amateur, but wasn’t vitrification about replacing the ice-crystal-generating water in the brain/body with a liquid that turns into a glass when cooled? If you can get that liquid into the furthest reaches of the brain, wouldn’t you also be able to distribute coolant through its interior, turning the effective cooling surface area proportional to the volume?
In this case cooling speed would be limited by the coolant flow and its thermal capacity and conductivity. You would have to use the cryoprotectant has a coolant. IIUC typical cyroprotectants are not good coolants at that temperature range. Nothing can be a good coolant close to its own glass transition temperature, since by definition their viscosity becomes very high (solid-like) at that temperature.
I am an absolute amateur, but wasn’t vitrification about replacing the ice-crystal-generating water in the brain/body with a liquid that turns into a glass when cooled? If you can get that liquid into the furthest reaches of the brain, wouldn’t you also be able to distribute coolant through its interior, turning the effective cooling surface area proportional to the volume?
In this case cooling speed would be limited by the coolant flow and its thermal capacity and conductivity. You would have to use the cryoprotectant has a coolant. IIUC typical cyroprotectants are not good coolants at that temperature range. Nothing can be a good coolant close to its own glass transition temperature, since by definition their viscosity becomes very high (solid-like) at that temperature.