IDEALLY, such a model would allow people to creative putative links to hand-annotate (with a dropdown menu) all the papers in support and against support of the model. https://genomics.senescence.info/genes/ exists but it isn’t great for mechanism as it’s just a long list of genes that seems to have been insight-free scraped. A lot of the aging-related genes people have studied in-depth that have shown the strongest associations for healthy aging (eg foxo3a/IGF1) sure *help* and then there are IGF mutants [oftentimes they dont directly increase repair] but I don’t feel that they’re as *fundamental* as, say, variations in proteasome function or catalase or splicesome/cell cycle checkpoint/DNA repair genes.
IDEALLY, such a model would allow people to creative putative links to hand-annotate (with a dropdown menu) all the papers in support and against support of the model. https://genomics.senescence.info/genes/ exists but it isn’t great for mechanism as it’s just a long list of genes that seems to have been insight-free scraped. A lot of the aging-related genes people have studied in-depth that have shown the strongest associations for healthy aging (eg foxo3a/IGF1) sure *help* and then there are IGF mutants [oftentimes they dont directly increase repair] but I don’t feel that they’re as *fundamental* as, say, variations in proteasome function or catalase or splicesome/cell cycle checkpoint/DNA repair genes.
I think you could enter such information into Wikidata.