Probabilities of basic cryonics tech working are questions of neuroscience, full stop
Is this your true objection? What potential discovery in neuroscience would cause you to abandon cryonics and actively look for other ways to preserve your identity beyond the natural human lifespan? (This is a standard question one asks a believer to determine whether the belief in question is rational—what evidence would make you stop believing?)
Anders Sandberg who does get the concept of sufficiently advanced technology posts saying, “Shit, turns out LTM seems to depend really heavily on whether protein blah has conformation A and B and the vitrification solution denatures it to C and it’s spatially isolated so there’s no way we’re getting the info back, it’s possible something unknown embodies redundant information but this seems really ubiquitous and basic so the default assumption is that everyone vitrified is dead”. Although, hm, in this case I’d just be like, “Okay, back to chopping off the head and dropping it in a bucket of liquid nitrogen, don’t use that particular vitrification solution”. I can’t think offhand of a simple discovery which would imply literally giving up on cryonics in the sense of “Just give up you can’t figure out how to freeze people ever.” I can certainly think of bad news for particular techniques, though.
I can’t think offhand of a simple discovery which would imply literally giving up on cryonics
OK. More instrumentally, then. What evidence would make you stop paying the cryo insurance premiums with CI as the beneficiary and start looking for alternatives?
Anders publishes that, CI announces they intend to go on vitrifying patients anyway, Alcor offers a chop-off-your-head-and-dunk-in-liquid-nitro solution. Not super plausible but it’s off the top of my head.
Not really, but yours is an uncharitable interpretation of my question, which is to evaluate the utility of spending some $100/mo on cryo vs spending it on something (anything) else, not “I have this dedicated $100/mo lying around which I can only spend toward my personal future revival”.
Personally, I would be very impressed if anyone could demonstrate memory loss in a cryopreserved and then revived organism, like a bunch of C. elegans losing their maze-running memories. They’re very simple, robust organisms, it’s a large crude memory, the vitrification process ought to work far better on them than a human brain, and if their memories can’t survive, that’d be huge evidence against anything sensible coming out of vitrified human brains no matter how much nanotech scanning is done (and needless to say, such scanning or emulation methods can and will be tested on a tiny worm with a small fixed set of neurons long before they can be used on anything approaching a human brain). It says a lot about how poorly funded cryonics research is that no one has done this or something similar as far as I know.
Hmm, I wonder how much has been done on figuring out the memory storage in this organism. Like, if you knock out a few neurons or maybe synapses, how much does it forget?
Since it’s C. elegans, I assume the answer is ‘a ton of work has been done’, but I’m too tired right now to go look or read more medical/biological papers.
I’m not totally sure I’d call this sufficient evidence since functional damage != many-to-one mapping but it would shave some points off the probability for existing tech and be a pointer to look for the exact mode of functional memory loss.
and actively look for other ways to preserve your identity beyond the natural human lifespan?
He’s kind of been working on that for a while now.
(I suppose that works either as “subvert the natural human lifespan entirely through creating FAI” or “preserve his identity for time immemorial in the form of ‘Harry-Stu’ fanfiction” depending on how cynical one is feeling.)
In my case, to name one contingency: if the NEMALOAD Project finds that analysis of relatively large cellular structures doesn’t suffice to predict neuronal activity, and concludes that the activity of individual molecules is essential to the process, then I’d become significantly more worried about EHeller’s objection and redo the cost-benefit calculation I did before signing up for cryonics. (It came out in favor, using my best-guess probability of success between 1 and 5 percent; but it wouldn’t have trumped the cost at, say, 0.1%.)
To name another: if the BPF shows that cryopreservation makes a hash of synaptic connections, I’d explicitly re-do the cost-benefit calculation as well.
Is this your true objection? What potential discovery in neuroscience would cause you to abandon cryonics and actively look for other ways to preserve your identity beyond the natural human lifespan? (This is a standard question one asks a believer to determine whether the belief in question is rational—what evidence would make you stop believing?)
Anders Sandberg who does get the concept of sufficiently advanced technology posts saying, “Shit, turns out LTM seems to depend really heavily on whether protein blah has conformation A and B and the vitrification solution denatures it to C and it’s spatially isolated so there’s no way we’re getting the info back, it’s possible something unknown embodies redundant information but this seems really ubiquitous and basic so the default assumption is that everyone vitrified is dead”. Although, hm, in this case I’d just be like, “Okay, back to chopping off the head and dropping it in a bucket of liquid nitrogen, don’t use that particular vitrification solution”. I can’t think offhand of a simple discovery which would imply literally giving up on cryonics in the sense of “Just give up you can’t figure out how to freeze people ever.” I can certainly think of bad news for particular techniques, though.
OK. More instrumentally, then. What evidence would make you stop paying the cryo insurance premiums with CI as the beneficiary and start looking for alternatives?
Anders publishes that, CI announces they intend to go on vitrifying patients anyway, Alcor offers a chop-off-your-head-and-dunk-in-liquid-nitro solution. Not super plausible but it’s off the top of my head.
No pun intended?
Can you name currently available alternatives to cryonics which accomplish a similar goal?
Apologies, misinterpreted the question.
Not really, but yours is an uncharitable interpretation of my question, which is to evaluate the utility of spending some $100/mo on cryo vs spending it on something (anything) else, not “I have this dedicated $100/mo lying around which I can only spend toward my personal future revival”.
Personally, I would be very impressed if anyone could demonstrate memory loss in a cryopreserved and then revived organism, like a bunch of C. elegans losing their maze-running memories. They’re very simple, robust organisms, it’s a large crude memory, the vitrification process ought to work far better on them than a human brain, and if their memories can’t survive, that’d be huge evidence against anything sensible coming out of vitrified human brains no matter how much nanotech scanning is done (and needless to say, such scanning or emulation methods can and will be tested on a tiny worm with a small fixed set of neurons long before they can be used on anything approaching a human brain). It says a lot about how poorly funded cryonics research is that no one has done this or something similar as far as I know.
Hmm, I wonder how much has been done on figuring out the memory storage in this organism. Like, if you knock out a few neurons or maybe synapses, how much does it forget?
Since it’s C. elegans, I assume the answer is ‘a ton of work has been done’, but I’m too tired right now to go look or read more medical/biological papers.
I’m not totally sure I’d call this sufficient evidence since functional damage != many-to-one mapping but it would shave some points off the probability for existing tech and be a pointer to look for the exact mode of functional memory loss.
He’s kind of been working on that for a while now.
(I suppose that works either as “subvert the natural human lifespan entirely through creating FAI” or “preserve his identity for time immemorial in the form of ‘Harry-Stu’ fanfiction” depending on how cynical one is feeling.)
In my case, to name one contingency: if the NEMALOAD Project finds that analysis of relatively large cellular structures doesn’t suffice to predict neuronal activity, and concludes that the activity of individual molecules is essential to the process, then I’d become significantly more worried about EHeller’s objection and redo the cost-benefit calculation I did before signing up for cryonics. (It came out in favor, using my best-guess probability of success between 1 and 5 percent; but it wouldn’t have trumped the cost at, say, 0.1%.)
To name another: if the BPF shows that cryopreservation makes a hash of synaptic connections, I’d explicitly re-do the cost-benefit calculation as well.