Because of false positives, seroprevalence is massively overestimated everywhere that there hasn’t been a massive outbreak. In those places the IFR is 1-2%. But can we extrapolate to normal outbreaks? If, as widely believed, an overrun medical system has worse mortality, then maybe the normal IFR really is only 0.5-1%. But if your meta-analysis directly measures that, it is not well-done.
Because of false positives, seroprevalence is massively overestimated everywhere that there hasn’t been a massive outbreak. In those places the IFR is 1-2%. But can we extrapolate to normal outbreaks? If, as widely believed, an overrun medical system has worse mortality, then maybe the normal IFR really is only 0.5-1%. But if your meta-analysis directly measures that, it is not well-done.