I’m not sure it can. I’ve read many different descriptions and looked at the math, but it’s a very different approach from the twin-based variance components estimation procedures I’ve managed to beat some understanding into my head of, and while I’ve worked with multilevel models & random effects in other contexts, the verbal descriptions of using multilevel models for estimating heritability just don’t make sense to me. (Judging from Visscher’s commentary paper, I may not be the only one having this problem.) I think my understanding of linear models and matrices may be too weak for it to click for me.
I’m not sure it can. I’ve read many different descriptions and looked at the math, but it’s a very different approach from the twin-based variance components estimation procedures I’ve managed to beat some understanding into my head of, and while I’ve worked with multilevel models & random effects in other contexts, the verbal descriptions of using multilevel models for estimating heritability just don’t make sense to me. (Judging from Visscher’s commentary paper, I may not be the only one having this problem.) I think my understanding of linear models and matrices may be too weak for it to click for me.