On the cost side: I’ve heard concerns that due to the delivery mechanism there might be a total number of mRNA shots (for any disease) you can use per lifetime, and side effects seem to increase per dose suggesting individuals might have a lifetime limit for any particular disease as well. If there is a lifetime limit, you want to think about how to allocate those across boosters and variants, and getting a third identical shot could be a huge waste.
The polyethylene glycol thing is discussed elsewhere on this page and I think they remember more specifics than I do. I do expect this problem is solvable, but you wouldn’t want to run out of mRNA shots before that happens.
The lifetime limit per disease is based on:
General knowledge of the immune system
Most people found the second shot worse than the first, although there are exceptions
My own response to the second shot was exceptionally bad, after a normal first shot (like, 99th percentile, still seeking medical treatment for it bad. I don’t regret getting the shot because I expect I also would have been an exceptionally bad covid case, but it does affect my cost/benefit calculation around further shots)
In the course of seeking treatment for my long term side effects, hearing from medical providers that they’re seeing a lot of people in the same boat. There’s no denominator on this of course, but it doesn’t seem to just be me.
I’m curious how much of a concern you think this is, now, 1 year later. I haven’t heard the “total number of mRNA shots (for any disease)”-concern from other places, and I’m wondering if that’s for good reasons.
On the cost side: I’ve heard concerns that due to the delivery mechanism there might be a total number of mRNA shots (for any disease) you can use per lifetime, and side effects seem to increase per dose suggesting individuals might have a lifetime limit for any particular disease as well. If there is a lifetime limit, you want to think about how to allocate those across boosters and variants, and getting a third identical shot could be a huge waste.
Huh, that’s really interesting. Do you have any sources around this? That sure could introduce some big shifts in the EV.
The polyethylene glycol thing is discussed elsewhere on this page and I think they remember more specifics than I do. I do expect this problem is solvable, but you wouldn’t want to run out of mRNA shots before that happens.
The lifetime limit per disease is based on:
General knowledge of the immune system
Most people found the second shot worse than the first, although there are exceptions
My own response to the second shot was exceptionally bad, after a normal first shot (like, 99th percentile, still seeking medical treatment for it bad. I don’t regret getting the shot because I expect I also would have been an exceptionally bad covid case, but it does affect my cost/benefit calculation around further shots)
In the course of seeking treatment for my long term side effects, hearing from medical providers that they’re seeing a lot of people in the same boat. There’s no denominator on this of course, but it doesn’t seem to just be me.
Could you send a link to the discussion/ any other source on this?
I’m curious how much of a concern you think this is, now, 1 year later. I haven’t heard the “total number of mRNA shots (for any disease)”-concern from other places, and I’m wondering if that’s for good reasons.