In regards to supplementation, oral melatonin supplements at 500mcg over a period of a week in shift workers did not influence basal secretion, as cessation for one day prior to measurements did not show differences when compared to secretion status prior to supplementation.[24] 24-hour melatonin levels in this study, when graphed, essentially overlapped suggesting next to no variance.[24] These results indicating a lack of negative feedback have been replicated with 2mg[25] and 5mg.[26]
Good question! This is definitely an important thing to consider.
300mcg initially. Currently at 200mcg to trigger sleep onset 6 hours before, 1.2mg timed-release, and a supplementary 300mcg timed-release or 200mcg if I wake up in the middle of the night.
It doesn’t appear to do that.:
Good question! This is definitely an important thing to consider.
One week is a trivial amount of time. I’ve been taking it for years and have had to slowly, steadily increase the dosage.
Do you have any evidence that the cause is not ordinary aging?
Interesting! If you don’t mind sharing, how much were you taking initially, and how much are you taking now?
300mcg initially. Currently at 200mcg to trigger sleep onset 6 hours before, 1.2mg timed-release, and a supplementary 300mcg timed-release or 200mcg if I wake up in the middle of the night.