“CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia.”
“In the modafinil group, in the post-drug period, we found an increase of centrality that occurred bilaterally in the BA17, thereby suggesting an increase of the FC of the visual cortex with other brain regions due to drug action.”
FC analysis revealed connectivity increase within the cerebellar Crus I, Crus II areas, and VIIIa lobule, the right inferior frontal sulcus (IFS), and the left middle frontal gyrus (MFG).”
“These frontal areas are known to modulate attention levels and some core processes associated with executive functions, and, specifically, inhibitory control and working memory (WM). These functions depend on each other and co-activate frontal areas along with the posterior visual cortex to re-orient attention toward visual stimuli and also enhance cognitive efficiency.
Data on behavioral effects of modafinil administration in our study group are missing and, at this stage, we can only provide theoretical speculations for the functional correlates of the regional activations that we have found to be promoted by the drug.”
“Modafinil-Induced Changes in Functional Connectivity in the Cortex and Cerebellum of Healthy Elderly Subjects”
http://journal.frontiersin.org/article/10.3389/fnagi.2017.00085/full
“CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia.”
“In the modafinil group, in the post-drug period, we found an increase of centrality that occurred bilaterally in the BA17, thereby suggesting an increase of the FC of the visual cortex with other brain regions due to drug action.” FC analysis revealed connectivity increase within the cerebellar Crus I, Crus II areas, and VIIIa lobule, the right inferior frontal sulcus (IFS), and the left middle frontal gyrus (MFG).”
“These frontal areas are known to modulate attention levels and some core processes associated with executive functions, and, specifically, inhibitory control and working memory (WM). These functions depend on each other and co-activate frontal areas along with the posterior visual cortex to re-orient attention toward visual stimuli and also enhance cognitive efficiency.
Data on behavioral effects of modafinil administration in our study group are missing and, at this stage, we can only provide theoretical speculations for the functional correlates of the regional activations that we have found to be promoted by the drug.”