Yes, if the potential effect size is large, you can get away with imprecise answers to some questions. But if there are many questions, at some point your “imprecision budget” will be spent. For example, will you be able to detect if your dosing leads to later hospitalization instead of no hospitalization? Or it weakens immunity instead of strengthening it?
I’m pretty optimistic that we have enough imprecision budget to work with if we put our heads together. Unfortunately, this comment section hasn’t been very lively so far.
Yes, if the potential effect size is large, you can get away with imprecise answers to some questions. But if there are many questions, at some point your “imprecision budget” will be spent. For example, will you be able to detect if your dosing leads to later hospitalization instead of no hospitalization? Or it weakens immunity instead of strengthening it?
I’m pretty optimistic that we have enough imprecision budget to work with if we put our heads together. Unfortunately, this comment section hasn’t been very lively so far.