I do this this technological hurdle can be overcome with sufficient research effort. Do note that part of the challenge of somatic editing of human brain cells is the absolute number of cells to be edited, and the volume of space those cells occupy, which are exponentially different in large human brains vs small mouse brains. These factors trade off against things like immune response time, which doesn’t vary based on brain size. So yeah, the challenge in a human-size brain will be bigger. How much bigger? I dunno. Still, I absolutely think it makes sense to start with small cheap animal models like mice and juvenile zebrafish, and then move into larger models like pigs.
I do this this technological hurdle can be overcome with sufficient research effort. Do note that part of the challenge of somatic editing of human brain cells is the absolute number of cells to be edited, and the volume of space those cells occupy, which are exponentially different in large human brains vs small mouse brains. These factors trade off against things like immune response time, which doesn’t vary based on brain size. So yeah, the challenge in a human-size brain will be bigger. How much bigger? I dunno. Still, I absolutely think it makes sense to start with small cheap animal models like mice and juvenile zebrafish, and then move into larger models like pigs.