The story I have heard is that fat cells, when they grow too large (from more energy in than out), create new fat cells, and when they grow smaller (because more energy out than in), shrink and send signals that say “please feed me” instead of disappearing.
If true, then it seems reasonable that you could have the lipostat mostly work as a ratchet, where it’s easier to grow accustomed to higher weights than lower weights.
[I think there’s some evidence against this story—you would expect liposuction to be more effective if this was the primary mechanism—but I think it’s more the case that lots of things are going on, and so nothing is only thing you have to think about.]
to clarify, I don’t understand why positive CICO can increase your weight set point but negative CICO can’t decrease it.
The story I have heard is that fat cells, when they grow too large (from more energy in than out), create new fat cells, and when they grow smaller (because more energy out than in), shrink and send signals that say “please feed me” instead of disappearing.
If true, then it seems reasonable that you could have the lipostat mostly work as a ratchet, where it’s easier to grow accustomed to higher weights than lower weights.
[I think there’s some evidence against this story—you would expect liposuction to be more effective if this was the primary mechanism—but I think it’s more the case that lots of things are going on, and so nothing is only thing you have to think about.]
Not an explanation, but type 2 diabetes is an example of a system failing(/adapting) in one direction and then not being reversible.