I...guess this isn’t wrong, but it’s a kind of Take I’ve never been able to relate to myself. Maybe it’s because I found Legit True Love at age 22, but I’ve never had that feeling of “oh no the men around me are too weak-willed” (not in my neck of the woods they’re not!) or “ew they’re too interested in going to the gym” (gym rats are fine? it’s a hobby that makes you good-looking, I’m on board with this) or “they’re not attentive and considerate enough” (often a valid complaint, but typically I’m the one who’s too hyperfocused on my own work & interests) or “they’re too show-offy” (yeah it’s irritating in excess but a little bit of show-off energy is enlivening).
Look: you like Tony Soprano because he’s competent and lives by a code? But you don’t like it when a real-life guy is too competitive, intense, or off doing his own thing? I’m sorry, but that’s not how things work.
Tony Soprano can be light-hearted and always have time for the women around him because he is a fictional character. In real life, being good at stuff takes work and is sometimes stressful.
My husband is, in fact, very close to this “Tony Soprano” ideal—assertive, considerate, has “boyish charm”, lives by a “code”, is competent at lots of everyday-life things but isn’t too busy for me—and I guarantee you would not have thought to date him because he’s also nerdy and argumentative and wouldn’t fit in with the yuppie crowd.
Also like. This male archetype is a guy who fixes things for you and protects you and makes you feel good. In real life? Those guys get sad that they’re expected to give, give, give and nobody cares about their feelings. I haven’t watched The Sopranos but my understanding is that Tony is in therapy because the strain of this life is getting to him. This article doesn’t seem to have a lot of empathy with what it’s like to actually be Tony...and you probably should, if you want to marry him.
a framework for thinking about aging: “1st gen” is delaying aging, which is where the field started (age1, metformin, rapamycin), while “2nd gen” is pausing (stasis), repairing (reprogramming), or replacing (transplanting), cells/tissues. 2nd gen usually uses less mature technologies (eg cell therapy, regenerative medicine), but may have a bigger and faster effect size.
“function, feeling, and survival” are the endpoints that matter.
biomarkers are noisy and speculative early proxies that we merely hope will translate to a truly healthier life for the elderly. apply skepticism.
links 10/23/24:
https://roamresearch.com/#/app/srcpublic/page/10-23-2024
https://eukaryotewritesblog.com/2024/10/21/i-got-dysentery-so-you-dont-have-to/ personal experience at a human challenge trial, by the excellent Georgia Ray
https://catherineshannon.substack.com/p/the-male-mind-cannot-comprehend-the
I...guess this isn’t wrong, but it’s a kind of Take I’ve never been able to relate to myself. Maybe it’s because I found Legit True Love at age 22, but I’ve never had that feeling of “oh no the men around me are too weak-willed” (not in my neck of the woods they’re not!) or “ew they’re too interested in going to the gym” (gym rats are fine? it’s a hobby that makes you good-looking, I’m on board with this) or “they’re not attentive and considerate enough” (often a valid complaint, but typically I’m the one who’s too hyperfocused on my own work & interests) or “they’re too show-offy” (yeah it’s irritating in excess but a little bit of show-off energy is enlivening).
Look: you like Tony Soprano because he’s competent and lives by a code? But you don’t like it when a real-life guy is too competitive, intense, or off doing his own thing? I’m sorry, but that’s not how things work.
Tony Soprano can be light-hearted and always have time for the women around him because he is a fictional character. In real life, being good at stuff takes work and is sometimes stressful.
My husband is, in fact, very close to this “Tony Soprano” ideal—assertive, considerate, has “boyish charm”, lives by a “code”, is competent at lots of everyday-life things but isn’t too busy for me—and I guarantee you would not have thought to date him because he’s also nerdy and argumentative and wouldn’t fit in with the yuppie crowd.
Also like. This male archetype is a guy who fixes things for you and protects you and makes you feel good. In real life? Those guys get sad that they’re expected to give, give, give and nobody cares about their feelings. I haven’t watched The Sopranos but my understanding is that Tony is in therapy because the strain of this life is getting to him. This article doesn’t seem to have a lot of empathy with what it’s like to actually be Tony...and you probably should, if you want to marry him.
https://fas.org/publication/the-magic-laptop-thought-experiment/ from Tom Kalil, a classic: how to think about making big dreams real.
https://paulgraham.com/yahoo.html Paul Graham’s business case studies!
https://substack.com/home/post/p-150520088 a celebratory reflection on the recent Progress Conference. Yes, it was that good.
https://en.m.wikipedia.org/wiki/Hecuba in some tellings (not Homer’s), Hecuba turns into a dog from grief at the death of her son.
https://www.librariesforthefuture.bio/p/lff
a framework for thinking about aging: “1st gen” is delaying aging, which is where the field started (age1, metformin, rapamycin), while “2nd gen” is pausing (stasis), repairing (reprogramming), or replacing (transplanting), cells/tissues. 2nd gen usually uses less mature technologies (eg cell therapy, regenerative medicine), but may have a bigger and faster effect size.
“function, feeling, and survival” are the endpoints that matter.
biomarkers are noisy and speculative early proxies that we merely hope will translate to a truly healthier life for the elderly. apply skepticism.
https://substack.com/home/post/p-143303463 I always like what Maxim Raginsky has to say. you can’t do AI without bumping into the philosophy of how to interpret what it’s doing.