I am pretty sure that SENS and de Grey are not underestimating the role of other types of biology research. Part of their strategy for getting research done is to identify research that could apply to the problem of longevity (even where the researcher may not have had that application in mind) and to provide grants for relevant follow up research.
Regarding the example of curing cancer, the maintenance approach endorsed by SENS may prevent a lot of cancer, and keep healthy the body’s natural immune response to stop cancer early. It seems to me that it would make more sense, to achieve the goal of healthy longevity, to put more resources into longevity research now, and then see what cancers and other diseases still threaten us, so we can focus our efforts on those specifically.
Aubrey de Grey has proposed comprehensively preventing cancer by eliminating genes that code for lengthening of telomeres altogether and supplementing with stem cells on a periodic basis. The periodic stem cell infusions would also act as a delivery mechanism for his proposed solution to the mitochondria problem, i.e. moving certain critical mitochondrial genes to the nucleus.
I think aging will take too long to cure for most of us to benefit from it, so I generally emphasize cryonics. But it is certainly fascinating to read de Grey’s proposals, and seems plausible enough that it could work soon if there is big money behind it, i.e. to be a good gamble. It has a high payout in total human lives saved, since (assuming rapid global distribution) developing it a day sooner would effectively save 100,000 people; thus even if one does not anticipate being alive to benefit, that is a significant charitable accomplishment.
Arguably the same is the case of suspended animation research—it could easily be that reversible cryopreservation would happen within our lifetimes if there was big money behind it. The beauty of suspended animation research is that it coincides with increasing the chances of cryonics working. Rejuvenation research is likely more applicable to the eventual reanimation phase of cryonics.
Aubrey de Grey has proposed comprehensively preventing cancer by eliminating genes that code for lengthening of telomeres altogether and supplementing with stem cells on a periodic basis.
Ah, so that’s how they intend to get around that problem—lengthen telomeres externally, where it’s safe.
I am pretty sure that SENS and de Grey are not underestimating the role of other types of biology research. Part of their strategy for getting research done is to identify research that could apply to the problem of longevity (even where the researcher may not have had that application in mind) and to provide grants for relevant follow up research.
Regarding the example of curing cancer, the maintenance approach endorsed by SENS may prevent a lot of cancer, and keep healthy the body’s natural immune response to stop cancer early. It seems to me that it would make more sense, to achieve the goal of healthy longevity, to put more resources into longevity research now, and then see what cancers and other diseases still threaten us, so we can focus our efforts on those specifically.
Aubrey de Grey has proposed comprehensively preventing cancer by eliminating genes that code for lengthening of telomeres altogether and supplementing with stem cells on a periodic basis. The periodic stem cell infusions would also act as a delivery mechanism for his proposed solution to the mitochondria problem, i.e. moving certain critical mitochondrial genes to the nucleus.
I think aging will take too long to cure for most of us to benefit from it, so I generally emphasize cryonics. But it is certainly fascinating to read de Grey’s proposals, and seems plausible enough that it could work soon if there is big money behind it, i.e. to be a good gamble. It has a high payout in total human lives saved, since (assuming rapid global distribution) developing it a day sooner would effectively save 100,000 people; thus even if one does not anticipate being alive to benefit, that is a significant charitable accomplishment.
Arguably the same is the case of suspended animation research—it could easily be that reversible cryopreservation would happen within our lifetimes if there was big money behind it. The beauty of suspended animation research is that it coincides with increasing the chances of cryonics working. Rejuvenation research is likely more applicable to the eventual reanimation phase of cryonics.
Ah, so that’s how they intend to get around that problem—lengthen telomeres externally, where it’s safe.
My woo-dar is tingling a bit regarding this proposal. Can you refer me to this research?
WILT is described here.