>For example, in 2003 the Nanoputian project successfully built a nanoscale model of a person out of organic molecules. They used cleverly chosen reaction pathways to produce the upper body, and cleverly chosen reaction pathways to produce the lower body, and then managed to pick the exact right conditions to mix them together in that would bond the two parts together
As a chemist by training, I don’t think this is actually that impressive. They basically did a few Sonogashira couplings, which are rather easy reactions (I did them regularly as an undergrad).
Another way to think about diamandoids is to consider what kind of organic chemistry you need to put them together the “traditional” way. That’ll give you some insight into the processes you’re going to be competing with as you try to assemble these structures, no matter which technique you use. The syntheses tend to go by rearrangements of other scaffolds that are easier to assemble but somewhat less thermodynamically stable (https://en.wikipedia.org/wiki/Diamantane#Production for example). However, this technique gets arduous beyond 4 or 5 adamantane units:
>For example, in 2003 the Nanoputian project successfully built a nanoscale model of a person out of organic molecules. They used cleverly chosen reaction pathways to produce the upper body, and cleverly chosen reaction pathways to produce the lower body, and then managed to pick the exact right conditions to mix them together in that would bond the two parts together
As a chemist by training, I don’t think this is actually that impressive. They basically did a few Sonogashira couplings, which are rather easy reactions (I did them regularly as an undergrad).
If you want something impressive, look at the synthesis of vitamin B12: https://en.wikipedia.org/wiki/Vitamin_B12_total_synthesis
Another way to think about diamandoids is to consider what kind of organic chemistry you need to put them together the “traditional” way. That’ll give you some insight into the processes you’re going to be competing with as you try to assemble these structures, no matter which technique you use. The syntheses tend to go by rearrangements of other scaffolds that are easier to assemble but somewhat less thermodynamically stable (https://en.wikipedia.org/wiki/Diamantane#Production for example). However, this technique gets arduous beyond 4 or 5 adamantane units:
https://en.wikipedia.org/wiki/Diamondoid
Agreed that the Nanoputians aren’t impressive. Lots of drugs are comparably complex, and they’re actually designed to elicit a biological effect.
The B12 synthesis is sweet, but I’ll put in a vote for the Woodward synthesis of strychnine (done using 1954 technology, no less!):
https://en.wikipedia.org/wiki/Strychnine_total_synthesis#Woodward_synthesis
Yeah, Woodward was a real trailblazer (interestingly, my undergrad PI was one of his last students)