I have posted this and following the advice of lesswrong members will clarify, the research was performed by me entirely late at night and passed through an LLM for readability.
You can view the original here, I believe it fulfils your criteria for being credible suggestions:
Before:
Aspirin is a credible better candidate than Tamiflu. First off safety profile because you need to weigh up risks and benefits. Short term usage (what you’re interested in for acute viral infections) is associated with GI upset, but only marginally more than placebo. There are of course other considerations that should be taken into account, but for the majority of users short term usage of aspirin is safe. Special note here about the association with aspirin and Reye’s syndrome in children, the incidence of this is extremely low, but it is worth considering if your patient is under 16. In terms of efficacy against H5N1, it has demonstrated great success in vitro and in vivo acting via its NF-κB-inhibiting activity.
Methylene blue is also a credible better candidate than Tamiflu. Starting again with safety profile the gist is short term usage is generally safe unless you happen to be contraindicated. There are a few reasons and these briefly (NOT comprehensive do not take medicine based off this comment alone) (i) if you are at risk of serotonin syndrome (ii) known hypersensitivity (iii) severe renal impairment. If you are considering this medication I implore you to read at least the following data sheet. With that out of the way, how well does it work against H5N1? Efficacy-wise it has little-appreciated broad-spectrum antiviral properties. and has specifically demonstrated potent virucidal activity against H1N1 (H5N1 not yet tested to my knowledge). Interestingly, there is also a patent application for this indication. Taken together it could credibly be better.
For balance, Tamiflu is also associated with many of the same common adverse side effects including nausea, vomiting, diarrhoea or abdominal pain. Side effects typically occur along a distribution of individual susceptibility and should be tolerable for most for all three drugs. However, efficacy wise, aspirin and methylene blue are both credible candidates at outperforming the benefits of Tamiflu against H5N1.
Yes. I have copied my shortform here in its entirety:
LessWrong, is this rational? I wrote a reply to Elizabeth’s open bid for answers to her research questions in good faith. She replies not with anything substantive, but to claim it is written with AI. I’m happy for her to disagree with my answer, but flagging a difference in style to suggest low quality is not what I thought this community was supposed to be about. Cynically, one could suggest she doesn’t want to make good on her offer … For the record, I wrote it late at night and ran the response through an LLM to improve readability for her benefit.
If you don’t know what I’m talking about, see the most disliked comment on her post :)
To be clear, I no longer think you were trying to avoid making good on your offer. But at the moment I was irked and that’s what it felt like from my perspective.
I have posted this and following the advice of lesswrong members will clarify, the research was performed by me entirely late at night and passed through an LLM for readability.
You can view the original here, I believe it fulfils your criteria for being credible suggestions:
Before:
Aspirin is a credible better candidate than Tamiflu. First off safety profile because you need to weigh up risks and benefits. Short term usage (what you’re interested in for acute viral infections) is associated with GI upset, but only marginally more than placebo. There are of course other considerations that should be taken into account, but for the majority of users short term usage of aspirin is safe. Special note here about the association with aspirin and Reye’s syndrome in children, the incidence of this is extremely low, but it is worth considering if your patient is under 16. In terms of efficacy against H5N1, it has demonstrated great success in vitro and in vivo acting via its NF-κB-inhibiting activity.
Methylene blue is also a credible better candidate than Tamiflu. Starting again with safety profile the gist is short term usage is generally safe unless you happen to be contraindicated. There are a few reasons and these briefly (NOT comprehensive do not take medicine based off this comment alone) (i) if you are at risk of serotonin syndrome (ii) known hypersensitivity (iii) severe renal impairment. If you are considering this medication I implore you to read at least the following data sheet. With that out of the way, how well does it work against H5N1? Efficacy-wise it has little-appreciated broad-spectrum antiviral properties. and has specifically demonstrated potent virucidal activity against H1N1 (H5N1 not yet tested to my knowledge). Interestingly, there is also a patent application for this indication. Taken together it could credibly be better.
For balance, Tamiflu is also associated with many of the same common adverse side effects including nausea, vomiting, diarrhoea or abdominal pain. Side effects typically occur along a distribution of individual susceptibility and should be tolerable for most for all three drugs. However, efficacy wise, aspirin and methylene blue are both credible candidates at outperforming the benefits of Tamiflu against H5N1.
Thank you for the explanation.
Is there a reason you deflected when I originally asked about AI assistance? To me that’s a much bigger deal than the AI assistance itself.
Yes. I have copied my shortform here in its entirety:
To be clear, I no longer think you were trying to avoid making good on your offer. But at the moment I was irked and that’s what it felt like from my perspective.