I found that Stuart A Kauffman’s “Demonstration That Cell Types Are Dynamical Attractors” a somewhat intuitive model for how cells could differentiate without needing many simultaneous low-probablity things to happen.
Basically, certain proteins can enhance or inhibit the generation of other proteins, which can do the same thing to the original proteins. This creates a circuit of sorts. I understood this part already.
What his paper explains is basically that large, randomly defined circuits have attractors, or stable loops that they tend to settle into. Large classes of random circuits will go to the same attractors, thus eliminating the requirement for fine-tuning of multiple variables in multicellular (and intracellular) processes.
I found that Stuart A Kauffman’s “Demonstration That Cell Types Are Dynamical Attractors” a somewhat intuitive model for how cells could differentiate without needing many simultaneous low-probablity things to happen.
Basically, certain proteins can enhance or inhibit the generation of other proteins, which can do the same thing to the original proteins. This creates a circuit of sorts. I understood this part already.
What his paper explains is basically that large, randomly defined circuits have attractors, or stable loops that they tend to settle into. Large classes of random circuits will go to the same attractors, thus eliminating the requirement for fine-tuning of multiple variables in multicellular (and intracellular) processes.