Yes, I agree, I think it is pretty unlikely. But not completely impossible. As I said it should be pretty easy to find them if they are in the lysate via, HP liquid chromatography. Brain penetrant cyclic peptides should on the whole be significantly less polar than acyclic polypeptides of similar mass.
Yes, I agree, I think it is pretty unlikely. But not completely impossible. As I said it should be pretty easy to find them if they are in the lysate via, HP liquid chromatography. Brain penetrant cyclic peptides should on the whole be significantly less polar than acyclic polypeptides of similar mass.