Another comment on timing updates: if you’re making a timing update for zoonosis vs DEFUSE, and you’re considering a long timing window w_z for zoonosis, then your prior for a DEFUSE leak needs to be adjusted for the short window w_d in which this work could conceivably cause a leak, so you end up with something like p(defuse_pandemic)/p(zoo_pandemic)= rr_d w_d/w_z, where rr_d is the riskiness of DEFUSE vs zoonosis per unit time. Then you make the “timing update” p(now |defuse_pandemic)/p(now |zoo_pandemic) = w_z/w_d and you’re just left with rr_d.
Another comment on timing updates: if you’re making a timing update for zoonosis vs DEFUSE, and you’re considering a long timing window w_z for zoonosis, then your prior for a DEFUSE leak needs to be adjusted for the short window w_d in which this work could conceivably cause a leak, so you end up with something like p(defuse_pandemic)/p(zoo_pandemic)= rr_d w_d/w_z, where rr_d is the riskiness of DEFUSE vs zoonosis per unit time. Then you make the “timing update” p(now |defuse_pandemic)/p(now |zoo_pandemic) = w_z/w_d and you’re just left with rr_d.
It’s not specifically DEFUSE, it’s DEFUSE and all possible related dangerous GoF work which became possible post 2017