Hmm. Do you mean if you ignore the evidence about how it does that in lots of other species—and that it produces similar short-term health improvements and metabolic changes in humans and other animals—and instead insist on only counting studies directly involving human longevity as evidence?
Yes. I’m one of those crazy people who wants to see calorie reduction actually extend human lives before I believe that calorie reduction extends human lives.
But I would be interested in seeing evidence that caloric reduction leads to “short-term health improvements” in humans.
Caloric restriction clearly can benefit the average American. The verdict is out on whether this is only because the average American has such an awful diet that decreasing consumption necessarily decreases consumption of an awful diet; however, the additional evidence from other species combines to be pretty compelling in my mind.
I don’t partake in chronic caloric restriction, but I fast occasionally, ideally as much as I can while maintaining the amount of muscle that I like to keep, and without dropping my productivity levels. The evidence in favor of the health benefits of intermittent fasting seems slightly better than CR, although I believe it is only beginning to get more attention in research.
“At present, although only limited information is available on the effect of CR on humans, credible data exist that allow us to make some reasonable predictions. For example, a 1994 European clinical study on non-obese, middle-aged subjects under a 10-week, 20% energy reduction (Velthuis-te Wierik et al. 1994), and the 2-year Biosphere experience (Walford et al. 1999, 2002)), produced promising human data on CR’s efficacies (Rae 2004). Further, a recent report (Fontana et al. 2004) shows CR’s beneficial effects, including the suppression of an atherosclerosis and inflammation biomarker in humans, solidifying the possibility of CR’s extension of human longevity. One clear-cut and most immediate sign of CR’s effect in human subjects is body weight reduction, as in the case of rodents. It is important to realize how simple weight reduction (mainly from loss of fat mass, particularly visceral adiposity) could have a strong impact on inflammation, insulin resistance, and diabetes in humans as reported recently (Dandona et al. 2004; Ferroni et al. 2004). If obesity is a state of inflammation and obesity-related insulin resistance is a chronic inflammatory disease, as indicated by biomarkers, then a reduction of adiposity by CR alone could exert a great improvement on human health and functional longevity, which is already widely accepted by many biomedical researchers.”
Hmm. Do you mean if you ignore the evidence about how it does that in lots of other species—and that it produces similar short-term health improvements and metabolic changes in humans and other animals—and instead insist on only counting studies directly involving human longevity as evidence?
Yes. I’m one of those crazy people who wants to see calorie reduction actually extend human lives before I believe that calorie reduction extends human lives.
But I would be interested in seeing evidence that caloric reduction leads to “short-term health improvements” in humans.
See here.
Caloric restriction clearly can benefit the average American. The verdict is out on whether this is only because the average American has such an awful diet that decreasing consumption necessarily decreases consumption of an awful diet; however, the additional evidence from other species combines to be pretty compelling in my mind.
I don’t partake in chronic caloric restriction, but I fast occasionally, ideally as much as I can while maintaining the amount of muscle that I like to keep, and without dropping my productivity levels. The evidence in favor of the health benefits of intermittent fasting seems slightly better than CR, although I believe it is only beginning to get more attention in research.
E.g.:
“At present, although only limited information is available on the effect of CR on humans, credible data exist that allow us to make some reasonable predictions. For example, a 1994 European clinical study on non-obese, middle-aged subjects under a 10-week, 20% energy reduction (Velthuis-te Wierik et al. 1994), and the 2-year Biosphere experience (Walford et al. 1999, 2002)), produced promising human data on CR’s efficacies (Rae 2004). Further, a recent report (Fontana et al. 2004) shows CR’s beneficial effects, including the suppression of an atherosclerosis and inflammation biomarker in humans, solidifying the possibility of CR’s extension of human longevity. One clear-cut and most immediate sign of CR’s effect in human subjects is body weight reduction, as in the case of rodents. It is important to realize how simple weight reduction (mainly from loss of fat mass, particularly visceral adiposity) could have a strong impact on inflammation, insulin resistance, and diabetes in humans as reported recently (Dandona et al. 2004; Ferroni et al. 2004). If obesity is a state of inflammation and obesity-related insulin resistance is a chronic inflammatory disease, as indicated by biomarkers, then a reduction of adiposity by CR alone could exert a great improvement on human health and functional longevity, which is already widely accepted by many biomedical researchers.”
http://www.springerlink.com/content/y4v8476763644335/fulltext.pdf