there is some interesting new papers showing RNA splicing and gene replication errors causing lots of age and degenerative disease, and the Tufts study shows a newly isolated protein that affects aging if in high enough concentration.
Uncovering a ‘smoking gun’ in age-related disease
“called splicing factor 1 (SFA-1) -- a factor also present in humans. In a series of experiments, the researchers demonstrate that this factor plays a key role in pathways related to aging. Remarkably, when SFA-1 is present at abnormally high levels, it is sufficient on its own to extend lifespan.”
“The error occurs as copies of three-letter sequences of DNA—known as CAG and CTG triplets—expand and repeat themselves hundreds or even thousands of times, disrupting normal gene sequences.” Genetic analyses in baker’s yeast now reveal that these large-scale expansions are controlled by genes that have been implicated in a process for repairing DNA breaks, leading the researchers to surmise that the expansions occur while breaks are being healed.”
there is some interesting new papers showing RNA splicing and gene replication errors causing lots of age and degenerative disease, and the Tufts study shows a newly isolated protein that affects aging if in high enough concentration.
Uncovering a ‘smoking gun’ in age-related disease
“called splicing factor 1 (SFA-1) -- a factor also present in humans. In a series of experiments, the researchers demonstrate that this factor plays a key role in pathways related to aging. Remarkably, when SFA-1 is present at abnormally high levels, it is sufficient on its own to extend lifespan.”
https://www.eurekalert.org/pub_releases/2016-12/htcs-ua120116.php
and
“The error occurs as copies of three-letter sequences of DNA—known as CAG and CTG triplets—expand and repeat themselves hundreds or even thousands of times, disrupting normal gene sequences.” Genetic analyses in baker’s yeast now reveal that these large-scale expansions are controlled by genes that have been implicated in a process for repairing DNA breaks, leading the researchers to surmise that the expansions occur while breaks are being healed.”
https://www.eurekalert.org/pub_releases/2016-12/tu-tru120216.php
and a special issue on regenerative medicine
Special Focus Issue: Regenerative medicine: past, present and future—Foreword
http://www.futuremedicine.com/toc/rme/11/8