The point about creating other problems sounds like it could be a real issue unless people are very careful. Maybe you have good data for identifying medical problems, but not knowing the causal pathway means weird stuff can happen. Lets say their is a gene that effects your sense of taste in such a way as to ruin (or significantly hamper) your enjoyment of food. That gene might anti-correlate with diabetes, but you probably wouldn’t want it.
I wouldn’t be suprised to find isolated examples like this, but if it were the case in general we’d expect to see people with low genetic risk scores for diabetes to have noticeably worse outcomes in some other area. And that’s just not what we see.
Frankly, the same can be said for a lot of other traits as well; to the degree that we do see plietropy (i.e. one gene having two effects), it tends to work in our favor: for example there are some genetic variants that both decrease risk of hypertension and decrease risk of heart attack.
I wouldn’t be suprised to find isolated examples like this, but if it were the case in general we’d expect to see people with low genetic risk scores for diabetes to have noticeably worse outcomes in some other area. And that’s just not what we see.
Frankly, the same can be said for a lot of other traits as well; to the degree that we do see plietropy (i.e. one gene having two effects), it tends to work in our favor: for example there are some genetic variants that both decrease risk of hypertension and decrease risk of heart attack.