This is where sibling validation becomes very useful: if the observed effect is due an actual direct genetic effect, it will allow you to distinguish siblings with higher and lower diabetes risk. If it’s due to some weird environmental gene correlation, it won’t.
If you did the sibling testing you would find that 10 of the associated genes replicated and 90 did not.
This is where sibling validation becomes very useful: if the observed effect is due an actual direct genetic effect, it will allow you to distinguish siblings with higher and lower diabetes risk. If it’s due to some weird environmental gene correlation, it won’t.
If you did the sibling testing you would find that 10 of the associated genes replicated and 90 did not.