In case anybody else doesn’t know the definition seems to be “Clinical and personal equipoise exists when a clinician has no good basis for a choice between two or more care options or when one is truly uncertain about the overall benefit or harm offered by the treatment to his/her patient.”
If that principle holds you are not allowed to run replication trials because in a replication trial you already have a good basis for believing that one of the groups gets a better treatment.
In case anybody else doesn’t know the definition seems to be “Clinical and personal equipoise exists when a clinician has no good basis for a choice between two or more care options or when one is truly uncertain about the overall benefit or harm offered by the treatment to his/her patient.”
If that principle holds you are not allowed to run replication trials because in a replication trial you already have a good basis for believing that one of the groups gets a better treatment.