In order to weigh about the possibility of long term effects of the MRNA covax (Pfizer, Moderna), we need some plausible categories of mechanism; my understanding is that a known-harmful spike protein is produced in some quantity (surely dose dependent; why do they dose large people the same as small?) which may cause some clots or other harms acutely, but then days later spike levels are back to zero at which point there’s nothing more to worry about except lingering cancer type damage that won’t heal fully, and autoimmune (more likely in case of response to covid exposure than broadly own-tissue-attacking which we’d have seen already after 100m doses). I’ve heard no specific evidence that the spike insult or the MRNA mechanism would cause either but those are the categories of risk as I see it, FWIW.
In order to weigh about the possibility of long term effects of the MRNA covax (Pfizer, Moderna), we need some plausible categories of mechanism; my understanding is that a known-harmful spike protein is produced in some quantity (surely dose dependent; why do they dose large people the same as small?) which may cause some clots or other harms acutely, but then days later spike levels are back to zero at which point there’s nothing more to worry about except lingering cancer type damage that won’t heal fully, and autoimmune (more likely in case of response to covid exposure than broadly own-tissue-attacking which we’d have seen already after 100m doses). I’ve heard no specific evidence that the spike insult or the MRNA mechanism would cause either but those are the categories of risk as I see it, FWIW.