I would also expect that the road is through creating models that predict off-target interactions. AlphaFold3 seems to be able to make some predictions about whether or not a given drug will bind with a particular proteins. Those aren’t yet 100 percent accurate but Isomorphic Laboratories probably already does this kind of modeling.
Knowing off-targets itself doesn’t tell you how exactly how serious the side-effects from hitting those off-targets happen to be but it’s quite useful and allows avoiding the most egregious drug candidates that hit the most of targets.
I would also expect that the road is through creating models that predict off-target interactions. AlphaFold3 seems to be able to make some predictions about whether or not a given drug will bind with a particular proteins. Those aren’t yet 100 percent accurate but Isomorphic Laboratories probably already does this kind of modeling.
Knowing off-targets itself doesn’t tell you how exactly how serious the side-effects from hitting those off-targets happen to be but it’s quite useful and allows avoiding the most egregious drug candidates that hit the most of targets.