Many inflammatory pathways are tightly regulated, often because they involve chain reactions.
Some of the PUFA metabolites, like 4HNE, can directly adduct to proteins and DNA.
Considering we are systems meant to detect small amounts of damage in order to mount an inflammatory response, even the tiniest amount of some of those hydroperoxides can be problematic.
Many of these molecules are reactive to UV light, and the most common report from the anti PUFA crowd is a complete stop to sunburns. Meaning people who used to burn within 10 minutes now require a few hours of direct exposure to get an inflammatory response.
I can confirm this on myself (I live in the desert).
Many inflammatory pathways are tightly regulated, often because they involve chain reactions. Some of the PUFA metabolites, like 4HNE, can directly adduct to proteins and DNA. Considering we are systems meant to detect small amounts of damage in order to mount an inflammatory response, even the tiniest amount of some of those hydroperoxides can be problematic. Many of these molecules are reactive to UV light, and the most common report from the anti PUFA crowd is a complete stop to sunburns. Meaning people who used to burn within 10 minutes now require a few hours of direct exposure to get an inflammatory response. I can confirm this on myself (I live in the desert).