Cells don’t just die of nothing. Their deaths have causes: causes like telomere attrition, genomic instability, cellular senescence, mitochondrial dysfunction, or loss of proteostasis.
The paper is not trying to enumerate every thing that changes for the worse with age (it doesn’t include immunosenescence, for example, even though that’s among the most important systemic changes you see with age). It’s trying to distill down to a list of things that cannot be adequately reduced to other processes.
Cells don’t just die of nothing. Their deaths have causes: causes like telomere attrition, genomic instability, cellular senescence, mitochondrial dysfunction, or loss of proteostasis.
The paper is not trying to enumerate every thing that changes for the worse with age (it doesn’t include immunosenescence, for example, even though that’s among the most important systemic changes you see with age). It’s trying to distill down to a list of things that cannot be adequately reduced to other processes.
You don’t need an increased amount of cell deaths for the cell deaths to become an issue without regeneration.
I would expect that some cells regularly die to all kinds of injury.