If large portion of effects of “sleep deprivations” can be reversed by drugs, it begs a question if they are effects of lack of sleep, or more side effect of the systems trying to get you to sleep.
Let’s take as a hypothesis that they are entirely of the latter kind, and modafinil and stimulants simply don’t turn off the sleep forcing system completely. Is there any strong evidence against it?
It’s trivial to point evidence against hypothesis that they’re entirely based on sleep deprivation, as even partial reversibility disproves it.
I’m also surprised by many of the procedures, which tried modafinil and/or stimulants as a single dose taken only after a lot (24h or more, often 36h+) of being forcefully awake. The right way that everyone uses them is to use them before first effects of sleepiness happen, which would be no later than about ~14h after waking up, and then boosting regularly every now and then, so you never go into sleepy phase. I don’t know if this affects the results, but intuitively it should make them less effective.
If large portion of effects of “sleep deprivations” can be reversed by drugs, it begs a question if they are effects of lack of sleep, or more side effect of the systems trying to get you to sleep.
Let’s take as a hypothesis that they are entirely of the latter kind, and modafinil and stimulants simply don’t turn off the sleep forcing system completely. Is there any strong evidence against it?
It’s trivial to point evidence against hypothesis that they’re entirely based on sleep deprivation, as even partial reversibility disproves it.
I’m also surprised by many of the procedures, which tried modafinil and/or stimulants as a single dose taken only after a lot (24h or more, often 36h+) of being forcefully awake. The right way that everyone uses them is to use them before first effects of sleepiness happen, which would be no later than about ~14h after waking up, and then boosting regularly every now and then, so you never go into sleepy phase. I don’t know if this affects the results, but intuitively it should make them less effective.