If the statistical significance of the studies are valid, then it’s quite unlikely that the lines would cross the x-axis. What Ionnidis is demonstrating is an overstatement of effect size in the initial studies.
Also, Yvain’s point that a cumulative odds ratio graph is different from a generic funnel plot.
If the statistical significance of the studies are valid, then it’s quite unlikely that the lines would cross the x-axis. What Ionnidis is demonstrating is an overstatement of effect size in the initial studies.
Also, Yvain’s point that a cumulative odds ratio graph is different from a generic funnel plot.