(I know that’s the title of the Nature paper, and kudos for stating “in mice” more prominently in the post body than the paper did, but IMO it’s worth appending to the title.)
While most SIRT1 knockout mice die perinatally, in a few weeks age, 129svJ background SIRT6 knockout mice exhibit severe developmental defects but survive to about 4 weeks of age. Similarly, in humans and primates, mutations resulting in SIRT6 inactivation result in prenatal or perinatal lethality accompanied by severe developmental brain defects.
This is maybe interesting as a suggestion of which pathways to investigate for aging-related loss of cellular energy homeostasis, but it’s not even plausible that it could be therapeutic in humans.
IN MICE
(I know that’s the title of the Nature paper, and kudos for stating “in mice” more prominently in the post body than the paper did, but IMO it’s worth appending to the title.)
This is maybe interesting as a suggestion of which pathways to investigate for aging-related loss of cellular energy homeostasis, but it’s not even plausible that it could be therapeutic in humans.